Analyte sensors and sensing methods featuring low-potential detection

US12044648B2 · kind B2 · utility

Assignee

• ABBOTT DIABETES CARE INC. · US

Inventors

• John V. LaTour · Alameda, US
• Jonathan D. McCanless · Memphis, US
• Stephen Oja · Alameda, US
• Tianmei Ouyang · Alameda, US
• Kevin P. Wallis · Alameda, US
• Benjamin J. Feldman · Oakland, US
• Udo Hoss · Ulm, DE
• Suyue Qian · Fremont, US

Key dates

• Filing date: Dec 23, 2020
• Grant date: Jul 23, 2024
• Expiry date: Dec 5, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/3277
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.