Arctigenin liquid nano-preparation and preparation method thereof

US12048684B2 · kind B2 · utility

Assignees

• Wuhan Academy of Agricultural Sciences · CN
• Hubei Wudang Animal Pharmaceutical Co., Ltd. · CN

Inventors

• Bin He · San Jose, US
• Lijun Wu · Ningbo City, CN
• Zheng-Rong Lu · 红钢城街道, CN
• Zhiping Ran · 红钢城街道, CN
• Guoming Chen · Shanghai, CN
• Zhiyong Shao · 红钢城街道, CN
• Xiabing Chen · 红钢城街道, CN
• Wei Liu · Hangzhou City, CN
• Ying Li · Millburn, US
• Wu-Han Liu · Miaoli City, TW
• Qi Zhou · Hitchin, GB
• Wenhai Yang · 红钢城街道, CN
• Dongqing Liu · 红钢城街道, CN
• Kangyu Du · 红钢城街道, CN

Key dates

• Filing date: Nov 16, 2022
• Grant date: Jul 30, 2024
• Expiry date: Nov 16, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted.