Cis-platinum cross-linked protein hydrogel and preparation method thereof
US12048715B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 29, 2023 |
| Grant date | Jul 30, 2024 |
| Priority date | — |
| Expiry date | Aug 29, 2043 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are a cis-platinum cross-linked protein hydrogel and a preparation method thereof. Main components of the cis-platinum cross-linked protein hydrogel comprise the following ingredients in percentage by mass: 0.5% to 5.0% drug, 6.0% to 50.0% serum albumin and 47.0% to 93.0% solvent medium; a carboxyl group on a surface of the serum albumin and the drug form a coordinate bond; and the drug is cis-platinum. A hydrogel preparation is simple in structure and easy to prepare, and the used cis-platinum has dual effects: a cross-linking agent for promoting the formation of protein hydrogels and an antitumor drug for exerting a tumor inhibition curative effect. The strategy simplifies the carrier design and reduces potential toxic side effects. The protein carboxyl limits the release of cis-platinum through a coordination effect so that reduce the burst release of the loaded drugs drastically.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.