Universal chimeric antigen receptor T-cell preparation technique

US12049487B2 · kind B2 · utility

Assignee

• GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. · CN

Inventors

• Xinxin Wang · Woodridge, US
• Zhongdong SHI · Shanghai, CN
• Liping Liu · Manassas, US
• Chunhui Yang · Durham, US
• Jing Sun · Suzhou, CN
• Songbai CAI · Shanghai, CN
• Wei CAO · Shanghai, CN

Key dates

• Filing date: Sep 6, 2018
• Grant date: Jul 30, 2024
• Expiry date: May 16, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a universal chimeric antigen receptor (CAR) T cell and preparation method and application thereof. The binding of the cell HLA-A/HLA-B to the TCR is inhibited; the TCR gene expression is silenced; the invention may be used for allogeneic tumor treatment and does not cause GVHD and HVG reaction during allogeneic infusion, and thus improves the survival and antineoplastic effect of allogeneic CAR-T cells in the recipient.