Bicyclic peptide ligands specific for CD137
US12049520B2 · kind B2 · utility
4Cited by
66References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 21, 2022 |
| Grant date | Jul 30, 2024 |
| Priority date | — |
| Expiry date | Jan 21, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.