Photo-curable bioink to fabricate ultra-strong, electroconductive, and biocompatible hydrogel for regenerative medicine
US12049570B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 2022 |
| Grant date | Jul 30, 2024 |
| Priority date | — |
| Expiry date | Aug 5, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2539/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present disclosure relates to the composition and process for the production of an ultra-strong, biocompatible, electroconductive, and stretchable hydrogel, which comprises: a step (a) of physical or chemical modification of natural polymers e.g., preparation of silk nanofiber and double methacrylation of gelatin; a step (b) of graphene oxide (GO) carboxylation; a step (c) of carbodiimidation between methacrylated natural polymers of step (a) and carboxylated GO of step (b); and a step (d) of three dimensional (3D) bioprinting of step (c) with/without silk nanofiber. It was found that these steps in this disclosure give rise to a biocompatible hydrogel with high mechanical strength in the range of load-bearing soft tissue such as tendon and heart as opposed to conventional hydrogels.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.