Patent · US Active

Ketoreductase polypeptides for the production of azetidinone

US12049649B2 · kind B2 · utility

0Cited by

55References

14Claims

0Family size

Assignee

Codexis, Inc. · US

Inventors

Onorato Campopiano · Hayward, US
Emily Mundorff · Garden City, US
Birthe Borup · Wesel, DE
Rama Voladri · Milpitas, US

Key dates

Filing date	Jun 24, 2021
Grant date	Jul 30, 2024
Priority date	—
Expiry date	Aug 21, 2041

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/52
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.