Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment
US12053514B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 17, 2014 |
| Grant date | Aug 6, 2024 |
| Priority date | — |
| Expiry date | Sep 17, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/64
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention encompasses therapeutic compositions including Globo H-KLH conjugates and/or therapeutic antibodies as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular the therapeutic conjugates include a Globo H moiety and a KLH moiety and/or a derivatized KLH moiety subunit optionally linked via a linker. The therapeutic compositions are in part envisaged to act as cancer vaccines for boosting the body's natural ability to protect itself, through the immune system from dangers posed by damaged or abnormal cells such as cancer cells. An effective immune response is one that reduces the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.