Radiolabeled microtubule imaging compounds and uses thereof

US12054463B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Dileep Kumar · New York, US
• J. John Mann · New York, US
• Akiva Mintz · Brooklyn, US
• Kiran K. Solingapuram Sai · Salem, US

Key dates

• Filing date: Oct 30, 2018
• Grant date: Aug 6, 2024
• Expiry date: Oct 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to radiolabeled compounds and methods of uses for diagnosis, monitoring, and treatment of various degenerative neurological disorders, neuropsychiatric disorders, brain injuries, vascular diseases, and cancers. Radiolabled compounds for imaging of microtubules or microtubules and other targets using positron-emission tomography (PET) are specifically disclosed.