Patent · US Active

Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide by racemate separation by means of diastereomeric tartaric acid esters

US12054481B2 · kind B2 · utility

1Cited by

1References

34Claims

0Family size

Assignees

BAYER HEALTHCARE LLC · DE
Bayer Pharma Aktiengesellschaft · DE

Inventors

Johannes Platzek · Berlin, DE
Kai Lovis · Düsseldorf, DE
Winfried Joentgen · Neunburg vorm Wald, DE

Key dates

Filing date	Apr 23, 2019
Grant date	Aug 6, 2024
Priority date	—
Expiry date	Aug 25, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also to the preparation of the enantiomer (Ia) by racemate resolution using chiral substituted tartaric acid esters of the general formulae (IIIa) and (IIIb) where Ar represents a substituted or unsubstituted aromatic or heteroaromatic radical.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.