Methods of determining nucleic acid structural information
US12054771B2 · kind B2 · utility
0Cited by
7References
22Claims
0Family size
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Key dates
| Filing date | Feb 17, 2015 |
| Grant date | Aug 6, 2024 |
| Priority date | — |
| Expiry date | Feb 14, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/30
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Methods of double-stranded nucleic acid sequence determination and assembly that are able to identify insertions, deletions, repeat region sizes and genomic rearrangements, for example, are disclosed herein, which can use relatively large labeled nucleic acid fragments to analyze the structure of even larger genetic regions. In some embodiments these methods involve the use of certain parameters which unexpectedly improve overall method performance. In some embodiments these methods involve sample labeling that does not result in the formation of single-stranded nucleic acid fragment labeling intermediaries.
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