Detection of tumor-derived DNA in cerebrospinal fluid

US12054781B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Chetan Bettegowda · Charlotte, US
• Kenneth W. Kinzler · Baltimore, US
• Bert Vogelstein · Baltimore, US
• Yuxuan Wang · Baltimore, US
• Luis Diaz · Ellicott City, US
• Nickolas Papadopoulos · Towson, US

Key dates

• Filing date: Jul 12, 2016
• Grant date: Aug 6, 2024
• Expiry date: Jul 12, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6886
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

As cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we assessed the cerebrospinal fluid (CSF) that bathes the CNS for tumor DNA, here termed CSF-tDNA. The results suggest that CSF-tDNA could be useful for the management of patients with primary tumors of the brain or spinal cord.