Processing of brain image data to assign voxels to parcellations

US12056876B2 · kind B2 · utility

Assignee

• Omniscient Neurotechnology Pty Limited · AU

Inventors

• Michael Edward Sughrue · Sydney, AU
• Stephane Philippe Doyen · Sydney, AU
• Charles Teo · Sydney, AU

Key dates

• Filing date: Jun 9, 2021
• Grant date: Aug 6, 2024
• Expiry date: Jun 4, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30016
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method (400) including: determining (702) a registration function [705, Niirf(T1)] for the particular brain in a coordinate space, determining (706) a registered atlas [708, Ard(T1)] from the registration function and an HCP-MMP1 Atlas (102) containing a standard parcellation scheme, performing (310, 619) diffusion tractography to determine a set [621, DTIp(DTI)] of brain tractography images of the particular brain, for a voxel in a particular parcellation in the registered atlas, determining (1105, 1120) voxel level tractography vectors [1123, Vje, Vjn] showing connectivity of the voxel with voxels in other parcellations, classifying (1124) the voxel based on the probability of the voxel being part of the particular parcellation, and repeating (413) the determining of the voxel level tractography vectors and the classifying of the voxels for parcellations of the HCP-MMP1 Atlas to form a personalised brain atlas [1131, PBs Atlas] containing an adjusted parcellation scheme reflecting the particular brain (Bbp).