Graphene-based nanosensor for identifying target analytes

US12059251B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Qiao Lin · Chengdu, CN
• Yibo Zhu · Issaquah, US
• Junyi Shang · New York, US
• Zhixing Zhang · 安丰镇, CN
• Xuejun Wang · Shanghai, CN
• Jaeyoung Yang · Seoul, KR
• Cheng-Kai Wang · New York, US
• Zhuang Hao · New York, US

Key dates

• Filing date: Mar 5, 2020
• Grant date: Aug 13, 2024
• Expiry date: Mar 5, 2040

Classification

• Technology area (CPC H): Electricity
• CPC primary: H10K85/20
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.