Compositions and methods for delivery of macromolecules

US12059407B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Niren Murthy · Atlanta, US
• Joachim Justad Roeise · Berkeley, US
• Chung Hak Taing · Berkeley, US

Key dates

• Filing date: Dec 3, 2018
• Grant date: Aug 13, 2024
• Expiry date: Feb 5, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides endosomal disruptors, which are useful for facilitating delivery of a macromolecule to the cytoplasm of a cell. The present disclosure provides compositions comprising an endosomal disruptor and a macromolecule. The present disclosure provides methods of delivering a macromolecule to the cytoplasm of a cell.