Engineered untranslated regions (UTR) for AAV production
US12060567B2 · kind B2 · utility
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Key dates
| Filing date | Jun 13, 2019 |
| Grant date | Aug 13, 2024 |
| Priority date | — |
| Expiry date | Nov 30, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure describes methods and systems for use in the production of recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system include engineered untranslated regions (UTR) which allow for the controlled expression of AAV capsid proteins, such as VP1, VP2 and VP3. In certain embodiments, the production process and system include engineered untranslated regions (UTR) which allow for the controlled expression of non-structural AAV replication proteins, such as Rep78 and Rep52.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.