Patent · US Active

Inducible AAV REP genes

US12060569B2 · kind B2 · utility

0Cited by

0References

17Claims

0Family size

Assignee

CEVEC Pharmaceuticals GmbH · DE

Inventors

Kerstin Hein · Cologne, DE
Nicole Faust · Cologne, DE
Silke Wissing · Cologne, DE

Key dates

Filing date	Apr 17, 2023
Grant date	Aug 13, 2024
Priority date	—
Expiry date	Apr 17, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2750/14152
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to host cells comprising a nucleic acid encoding Adeno-associated virus (AAV) Rep proteins Rep78 and Rep68, wherein the internal AAV promoter p19 has been inactivated by one or more mutations that maintain the functionality of said Rep78 and Rep68 proteins. The present invention further relates to respective nucleic acids and vectors comprising the same, as well as respective methods for the production of AAV.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.