Patent · US Active

Lov-D acyltransferase mediated acylation

US12060592B2 · kind B2 · utility

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Key dates

Filing dateNov 4, 2020
Grant dateAug 13, 2024
Priority date
Expiry dateApr 5, 2042

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02P20/52
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.