Human antibody-producing non-human animal and method for preparing human antibodies using same
US12063913B2 · kind B2 · utility
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Key dates
| Filing date | Oct 31, 2017 |
| Grant date | Aug 20, 2024 |
| Priority date | — |
| Expiry date | Nov 3, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8518
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This application provides: a non-human animal that comprises a mouse artificial chromosome comprising a human antibody heavy chain gene or gene locus, a human antibody light chain κ gene or gene locus, and/or a human antibody light chain λ gene or gene locus, and in which endogenous antibody genes or gene loci corresponding to at least 2 human antibody genes or gene loci have been knocked out, wherein the animal can be stably retained through generations and can produce human antibodies; a method for producing the non-human animal; and a method for producing human antibodies using the non-human animal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.