Biochemical and biomechanical conditioning for enhancing personalized mesenchymal stem cell therapies
US12064453B2 · kind B2 · utility
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Key dates
| Filing date | Sep 26, 2018 |
| Grant date | Aug 20, 2024 |
| Priority date | — |
| Expiry date | Dec 4, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2527/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A high-throughput screening system is provided for optimizing the conditioning of patient-specific mesenchymal stem cells using a combinatorial set of biochemical factors, pharmacological inhibitors, and biomechanical forces. Also provided are generalized conditions for performing such conditioning. Cells made by these methods are also provided, in addition to cells having a mixed endothelial cell/pericyte phenotype. These cells produce angiogenic growth factors and induce vascularization following implantation.
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