Dual cytokine fusion proteins comprising IL-10
US12065473B2 · kind B2 · utility
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Key dates
| Filing date | Nov 3, 2023 |
| Grant date | Aug 20, 2024 |
| Priority date | — |
| Expiry date | Nov 3, 2043 |
Classification
- Technology area (CPC —)General
Abstract
The application relates to a dual cytokine fusion protein composition, pharmaceutical composition, and/or formulation thereof comprising IL-10 or IL-10 variant molecules fused to a single chain variable fragment scaffolding system and a second cytokine, where the second cytokine is linked in the hinge region of the scFv. The application also relates to methods of using the dual cytokine fusion protein composition for treating cancer, inflammatory diseases or disorders, and immune and immune mediated diseases or disorders.
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