T cell receptors and fusion proteins thereof
US12065475B2 · kind B2 · utility
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27References
21Claims
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Key dates
| Filing date | Dec 15, 2023 |
| Grant date | Aug 20, 2024 |
| Priority date | — |
| Expiry date | Dec 15, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides T cell receptor (TCR) fusion proteins comprising a TCR that binds to a GVYDGREHTV (SEQ ID NO:34) HLA-A*02 complex that is covalently linked to a T cell engaging domain that binds a protein expressed on a cell surface of a T cell and an antibody Fc domain, as well as polynucleotides, vectors, kits, host cells, pharmaceutical compositions, methods, and uses related thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.