Claudin-6 antibodies and drug conjugates

US12065489B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Dylan Conklin · Los Angeles, US
• Martina S. McDermott · Los Angeles, US
• Neil A. O'Brien · Los Angeles, US
• Michael J. Palazzolo · Los Angeles, US
• Dennis Slamon · Los Angeles, US
• Erika Von Euw · Los Angeles, US
• Peter Bowers · San Diego, US

Key dates

• Filing date: Jun 22, 2022
• Grant date: Aug 20, 2024
• Expiry date: Jun 22, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.