High-yielding continuous flow synthesis of antimalarial drug hydroxychloroquine

US12071410B2 · kind B2 · utility

Assignee

• Virginia Commonwealth University · US

Inventors

• Frank Gupton · Midlothian, US
• Saeed Ahmad · Swift Creek Farms, US
• Hari P. R. Gunuru · Forest Meadow Mobile Home Park, US
• Nakul Telang · University, US

Key dates

• Filing date: Feb 25, 2019
• Grant date: Aug 27, 2024
• Expiry date: Jan 28, 2041

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)-amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.