10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza

US12071441B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Maxime Dauphinais · Emeryville, US
• Rama Jain · Danville, US
• Dennis Christofer Koester · Emeryville, US
• James R. MANNING · Pleasant Hill, US
• Vanessa M. Marx · Pasadena, US
• Daniel Poon · Piedmont, US
• Lifeng Wan · Richmond, US
• Xiaojing Wang · Foster City, US
• Aregahegn Yifru · Benicia, US
• Qian Zhao · Louisville, US

Key dates

• Filing date: Feb 27, 2023
• Grant date: Aug 27, 2024
• Expiry date: Feb 27, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.