Anti-human kallikrein-2 (hK2) chimeric antigen receptor (CAR) and methods of use thereof

US12071466B2 · kind B2 · utility

Assignee

• JANSSEN BIOTECH, INC. · US

Inventors

• Raymond Brittingham · Spring House, US
• Rajkumar Ganesan · Blue Bell, US
• Sherry Lynn La Porte · Horsham, US
• John Lee · Philadelphia, US
• Jinquan Luo · Malvern, US
• Theresa McDevitt · Warminster, US
• Fei Shen · Philadelphia, US
• Sanjaya Singh · Sandy Hook, US
• Degang Song · Wynnebrook Manor, US
• Sathyadevi VENKATARAMANI · Blue Bell, US
• Fang Yi · Collegeville, US
• Yonghong Zhao · Eagleville, US

Key dates

• Filing date: Jul 23, 2020
• Grant date: Aug 27, 2024
• Expiry date: Oct 20, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.