Site-specific crosslinking of antibodies
US12071487B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Jun 16, 2017 |
| Grant date | Aug 27, 2024 |
| Priority date | — |
| Expiry date | Dec 6, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3513
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for making bispecific antibodies and antibody conjugates comprising site-specifically cross-linking two or more antibodies, antibody fragments or Fc-fusion proteins. Also provided are compositions and uses for the bispecific antibodies and antibody conjugates. The bispecific antibodies may be used to treat a disease or condition. Also provided are methods for site-specifically conjugating a liposome, an mRNA or an siRNA to an antibody, and uses of the antibody-conjugated liposome, mRNA or siRNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.