Strongly-interacting magnetic particle imaging

US12072400B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• University of Florida Research Foundation, INC. · US

Inventors

• Steven M. Conolly · Walnut Creek, US
• Carlos Rinaldi · Gainesville, US
• Bo Zheng · Aurora, US
• Prashant Chandrasekharan · Berkeley, US
• Daniel Hensley · Emeryville, US
• Shehaab Savliwala · Gainesville, US
• Zhi Wei Tay · Berkeley, US
• Rohan Deepak Dhavalikar · Hillsboro, US

Key dates

• Filing date: Jul 23, 2020
• Grant date: Aug 27, 2024
• Expiry date: Aug 6, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/0515
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A magnetic particle imaging system that includes a magnetic field generating system with at least one magnet and providing a gradient magnetic field within an observation region such that the gradient magnetic field has a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein. The magnetic field generating system also includes a drive field and a slow shift field that dynamically shifts the FFR across a field of view (FOV) within the observation region, where the trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the particles in the FOV are saturated to a full coercivity field prior to traversing to an opposite-polarity of coercivity. The magnetic particle imaging system also includes a detection system proximate the observation region and configured to detect a signal from the strongly-interacting magnetic particles. The magnetic particle imaging system further includes signal processor in communication with the detection system, configured to receive and process the detected signal to remove a coercivity shift due to the coercivity …