Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof

US12076315B2 · kind B2 · utility

Assignee

• Clear Creek Bio, Inc.

Inventors

• Abdolsamad Tadayon · Kirkland, CA
• Ping Huang · Mountain View, US
• Chaoyi Deng · Shanghai, CN
• Jinsuo Yang · Shanghai, CN
• Qingqing Lu · Shanghai, CN
• Lin Cui · Shanghai, CN
• Mo Jia · Shanghai, CN
• Xianjun You · Shanghai, CN
• David P. Hesson · Malvern, US
• Siyi Jiang · Shanghai, CN

Key dates

• Filing date: Mar 19, 2021
• Grant date: Sep 3, 2024
• Expiry date: Oct 16, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions containing a stable crystalline form of brequinar and methods of making such composition. The invention also provides methods of using such compositions to treat a condition in a subject.