Variant sulfatase enzymes with enhanced properties
US12076377B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Oct 26, 2022 |
| Grant date | Sep 3, 2024 |
| Priority date | — |
| Expiry date | Oct 26, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/06013
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mutated Pseudomonas aeruginosa sulfatase (PaS) enzymes with enhanced enzymatic activity as compared to the parental wild type enzyme are provided. The variant sulfatases of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs. Methods of using the mutated enzymes for hydrolysis of sulfate ester linkages are also provided, including with substrates such as opioids or steroids containing a sulfate ester linkage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.