Methods and compositions for immune protection against extra-intestinal pathogenic E. coli
US12076385B2 · kind B2 · utility
0Cited by
19References
22Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Sep 23, 2022 |
| Grant date | Sep 3, 2024 |
| Priority date | — |
| Expiry date | Sep 23, 2042 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.