Polymorphs of a dihydroorotate dehydrogenase (DHOD) inhibitor

US12077517B2 · kind B2 · utility

Assignee

• Panoptes Pharma GmbH · AT

Inventors

• Stefan Sperl · Birkenfeld, DE
• Lisa Plasser · Wien, AT
• Osama Suleiman · Cambridge, GB
• Christopher Scott · Foxford, IE
• Susana DEL RIO GANCEDO · Cambridge, GB
• Joseph Stephen Harris · Cambridge, GB

Key dates

• Filing date: Feb 22, 2023
• Grant date: Sep 3, 2024
• Expiry date: Feb 22, 2043

Classification

• Technology area (CPC —): General

Abstract

The present disclosure provides polymorphs of 3-(2,3,5,6-tetrafluoro-3′-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid, and methods of making such polymorphs. The present disclosure further provides pharmaceutical compositions and kits comprising polymorphs of the invention, and methods of treating, preventing, or ameliorating a disease or condition comprising administering a polymorph of the invention.