Anti-PACAP antibodies and uses thereof

US12077581B2 · kind B2 · utility

Assignee

• H. LUNDBECK A/S · DK

Inventors

• Maria-Cristina Loomis · Bothell, US
• Leon F. Garcia-Martinez · Woodinville, US
• Benjamin H. Dutzar · Seattle, US
• Daniel S. Allison · Lake Forest Park, US
• Katherine Lee Hendrix · Bothell, US
• Ethan W. Ojala · Snohomish, US
• Pei Fan · Bothell, US
• Jeffrey T. L. Smith · Dublin, IE
• John Latham · Seattle, US
• Charlie Karasek · Seattle, US
• Jenny Mulligan · Lake Forest Park, US
• Michelle Scalley-Kim · Seattle, US
• Erica Stewart · Seattle, US
• Vanessa Lisbeth Rubin · Seattle, US
• Jens J. Billgren · Seattle, US

Key dates

• Filing date: Dec 16, 2021
• Grant date: Sep 3, 2024
• Expiry date: Dec 16, 2041

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.