GPRC5D chimeric antigen receptors and cells expressing the same

US12077592B2 · kind B2 · utility

Assignee

• JANSSEN BIOTECH, INC. · US

Inventors

• Ricardo Attar · Lawrenceville, US
• Rajkumar Ganesan · Blue Bell, US
• Francois Gaudet · Princeton, US
• Bradley J. Heidrich · Gilbertsville, US
• Carmen Baca Jones · Sharonville, US
• John Lee · Philadelphia, US
• Yingzhe Li · Dresher, US
• Sanjaya Singh · Sandy Hook, US
• Sathya Venkataramani · Blue Bell, US

Key dates

• Filing date: Jan 15, 2020
• Grant date: Sep 3, 2024
• Expiry date: Oct 23, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for the treatment of cancer.