Patent · US Active

Bioactive conjugates for oligonucleotide delivery

US12077755B2 · kind B2 · utility

0Cited by

82References

11Claims

0Family size

Assignee

University of Massachusetts · US

Inventors

Anastasia Khvorova · Boulder, US
Mehran Nikan · Boston, US
Matthew Hassler · Worcester, US
Maire Osborn · Boston, US
Reka Haraszti · Tübingen, DE
Andrew Coles · Boston, US
Anton Turanov · Boston, US
Neil Aronin · Newton, US

Key dates

Filing date	Mar 9, 2020
Grant date	Sep 3, 2024
Priority date	—
Expiry date	Oct 29, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.