Compositions and methods for analyte detection using nanoswitches

US12077807B2 · kind B2 · utility

Assignees

• The Research Foundation for The State University of New York · US
• Children's Medical Center Corporation · US

Inventors

• Arun Richard Chandrasekaran · Albany, US
• Clinton H. Hansen · Cambridge, US
• Mounir A. KOUSSA · Kitchener, CA
• Kenneth Anders Halvorsen · Natick, US
• Wesley Philip Wong · Cambridge, US

Key dates

• Filing date: Jun 27, 2016
• Grant date: Sep 3, 2024
• Expiry date: Aug 17, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/027
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Provided herein are nucleic acid-based nanoswitches that can detect specific nucleic acids and other analytes types by for example a simple gel electrophoresis readout. Binding of the target to the nanoswitches induces a conformation change from a linear, open conformation to a looped, closed conformation. These nanoswitches may be used in diagnostic assays such as nucleic acid-based diagnostic assays, to detect, measure and/or purify a variety of targets including low abundance targets.