Fast-track humanisation of specific binding molecules
US12077882B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Sep 15, 2022 |
| Grant date | Sep 3, 2024 |
| Priority date | — |
| Expiry date | Sep 15, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a synthetic library of humanised antigen specific binding molecules derived from a member of a species in the Elasmobranchii subclass, processes for the production thereof and specific antigen specific binding molecules isolated from said library. The present invention also relates to the multi-domain specific binding molecules comprising humanised Ig-like Novel Antigen Receptor variable domains (VNARs). Specific binding domains that bind to Tumour Necrosis Factor alpha (TNFα) are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.