Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent

US12084415B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Jeremiah A. Johnson · Boston, US
• Hung Vanthanh Nguyen · Cambridge, US
• Peyton Shieh · Cambridge, US
• Wencong Wang · Cambridge, US
• Bin Liu · Fishers, US
• Valerie Lensch · Cambridge, US
• Landon Kilgallon · Cambridge, US
• Yutong Dai · Somerville, US
• Samantha Lynn Kristufek · Lubbock, US

Key dates

• Filing date: Oct 20, 2022
• Grant date: Sep 10, 2024
• Expiry date: Oct 20, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G2261/418
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, mucoprotein, lipoprotein, glycoprotein, or polynucleotide; and (2) a polymer comprising a pharmaceutical agent. The conjugates may be useful in delivering (e.g., targeted delivering) the pharmaceutical agent to a subject in need thereof or cell or treating, preventing, or diagnosing a disease.