Pharmaceutical salts of pyrimidine derivatives and method of treating disorders

US12084431B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Landon J. Durak · Cambridge, US
• Marianne Langston · North Andover, US
• Pradeep Sharma · Westford, US
• Thai Hiep Nguyen · Fair Lawn, US
• Shuanglian Li · Lexington, US
• Xiaoguang Zhang · Macungie, US

Key dates

• Filing date: May 13, 2019
• Grant date: Sep 10, 2024
• Expiry date: Sep 23, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to pharmaceutical salts and polymorphic forms of pyrimidine derivatives that have inhibitory activities against mutant epidermal growth factor receptor (EGFR). The present disclosure further relates to the processes for the preparation of the pyrimidine derivatives and to the pharmaceutical salts and the polymorphic forms of the pyrimidine derivatives.