Ubiquitin high affinity cyclic peptides and methods of use thereof
US12084523B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Nov 8, 2022 |
| Grant date | Sep 10, 2024 |
| Priority date | — |
| Expiry date | Nov 8, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a cyclic polypeptide having ubiquitin binding affinity (KD) of 0.1-100 nM. Further provided are methods for reducing deubiquitination activity of a cell, and for treating cancer in a subject in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.