Nucleic acids comprising a modified rodent activin a receptor type 1 (Acvr1) gene
US12089576B2 · kind B2 · utility
0Cited by
6References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 7, 2022 |
| Grant date | Sep 17, 2024 |
| Priority date | — |
| Expiry date | Jul 27, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/30
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in antisense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.