Methods of treating glioblastomas

US12090170B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Wendell A. Lim · San Francisco, US
• Hideho Okada · Mill Valley, US
• Kole T. Roybal · San Francisco, US
• Joseph H. Choe · San Francisco, US
• Payal B. Watchmaker · San Francisco, US

Key dates

• Filing date: Apr 4, 2019
• Grant date: Sep 17, 2024
• Expiry date: Sep 28, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods are provided for treating a subject for glioblastoma, including e.g., an EGFRvIII negative glioblastoma. The methods of the present disclosure involve administering to a subject a molecular circuit that includes a binding triggered transcriptional switch (BTTS) that binds to a priming antigen expressed by the subjects glioblastoma multiforme (GBM) that, when bound to the priming antigen, induces one or more encoded therapeutics specific for one or more antigens expressed by the GBM. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods.