Surfactant microbubbles compositions and process for preparing thereof
US12090203B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 29, 2020 |
| Grant date | Sep 17, 2024 |
| Priority date | — |
| Expiry date | Apr 15, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M37/0092
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for preparing acoustically-sensitive microbubbles. The method includes the steps of: i) preparing a first surfactant solution comprising a first micelle-forming surfactant at a concentration above the critical micelle concentration (CMC); ii) adding one or more pharmaceutical compounds in a solvent to the first surfactant solution, thereby loading the micelles with the one or more pharmaceutical compounds; iii) preparing a second surfactant solution comprising a second surfactant, wherein the second surfactant comprises one or more matrix forming surfactants; iv) adding heat to the second surfactant solution to melt the surfactant and allowing the mixture to cool under rapid stirring; v) combining the second surfactant solution with the loaded micelles; vi) purging the surfactant mixture with a purging gas; vii) agitating the purged mixture under a constant stream of the purging gas; and, viii) separating the formed microbubbles by size.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.