Compositions for modulation of a TREM or TREML protein and methods of use
US12091455B2 · kind B2 · utility
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31Claims
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Key dates
| Filing date | Feb 14, 2019 |
| Grant date | Sep 17, 2024 |
| Priority date | — |
| Expiry date | Jan 19, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for reducing inflammation. In one aspect, the present invention provides a protein inhibitor comprising an ectodomain of at least one TREM or TREML protein. The invention also relates to inhibiting the interaction between a TREM or TREML protein and mitochondria released or derived from necroptotic cells; or between a TREM or TREML protein and cardiolipin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.