Patent · US Active

Development of spinal cord on a microfluidic chip

US12091650B2 · kind B2 · utility

0Cited by

1References

20Claims

0Family size

Assignee

EMULATE, INC. · US

Inventors

S. Jordan Kerns · Reading, US
Norman Wen · Dedham, US
Carolina Lucchesi · Westwood, US
Christopher David Hinojosa · Cambridge, US
Jacob Fraser · Somerville, US
Geraldine Hamilton · Cambridge, US
Gad Vatine · Los Angeles, US
Samuel Sances · Santa Monica, US
Clive Svendsen · Santa Monica, US
Daniel Levner · Brookline, US
Dhruv Sareen · Deer Lake Highlands, US

Key dates

Filing date	Feb 26, 2019
Grant date	Sep 17, 2024
Priority date	—
Expiry date	Feb 4, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2539/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.