Patent · US Active

Method of determining the concentration of at least one compound in a chromatography device

US12092621B2 · kind B2 · utility

0Cited by

4References

15Claims

0Family size

Assignee

Sartorius Stedim Biotech GmbH · DE

Inventors

Jan Schwellenbach · Göttingen, DE
Volkmar Thom · Oettingen, DE
Dominik Stein · Göttingen, DE

Key dates

Filing date	May 8, 2020
Grant date	Sep 17, 2024
Priority date	—
Expiry date	Mar 28, 2041

Classification

Technology area (CPC G)Physics
CPC primaryG01N2030/8831
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to a method of determining the concentration of at least one compound in a chromatography method, wherein fluctuations of the stationary phase's spatial structure due to variations of the composition of the mobile phase and/or the chromatography temperature are considered by calculating the concentration c(z, t) based on the flow velocity ν and the bulk porosity εb, which may vary due to the varying composition and/or temperature and which are determined for the varying composition of the mobile phase and/or the varying chromatography temperature.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.