Sequential treatment of cancers using 6-thio-dG, checkpoint inhibitors and radiation therapy
US12097213B2 · kind B2 · utility
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Key dates
| Filing date | Mar 12, 2021 |
| Grant date | Sep 24, 2024 |
| Priority date | — |
| Expiry date | Jul 22, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2′-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. Leads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.
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