Dual mode gadolinium nanoparticle contrast agents

US12097269B2 · kind B2 · utility

Inventors

• Vikas Kundra · Missouri City, US
• James A. Bankson · Pearland, US
• Ananth Annapragada · Manvel, US
• Ketan B. Ghaghada · Houston, US
• Murali K. Ravoori · Pearland, US

Key dates

• Filing date: Oct 27, 2011
• Grant date: Sep 24, 2024
• Expiry date: Jan 7, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are nanoparticle-based gadolinium (Gd) agents which may be used, e.g., in T1-weighted MR imaging (MRI). In various embodiments, dual-Gd liposomal agents are provided which contain both core-encapsulated Gd as well as surface-conjugated Gd. In various embodiments, these agents were observed to deliver a higher concentrations of Gd and result in substantial improvements in signal to noise ratios and contrast to noise ratios. Also provided are methods for in vivo imaging and/or treating diseases such as cancer or tumor in a subject.