Self-assembled nanoparticle containing gB protein of EB virus and preparation method and use thereof

US12098167B2 · kind B2 · utility

Assignees

• SUN YAT-SEN UNIVERSITY · CN
• SUN YAT-SEN UNIVERSITY CANCER CENTER (SYSUCC) · CN

Inventors

• Musheng Zeng · Longbeilingcun, CN
• Cong Sun · Qingdao, CN
• Yixin Zeng · Ebeye, US
• Guokai Feng · Longbeilingcun, CN
• Yinfeng KANG · Longbeilingcun, CN
• Xinchun Chen · Xi'an, CN
• Xiao ZHANG · Loma Linda, US
• Qianying Zhu · Beijing, CN
• Jiangping Li · Longbeilingcun, CN
• Xiangwei Kong · Lo Wu, CN

Key dates

• Filing date: Dec 15, 2020
• Grant date: Sep 24, 2024
• Expiry date: Dec 15, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to a self-assembled nanoparticle containing a gB protein of an EB virus and a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide; the first polypeptide comprises the gB protein and a first vector subunit, the second polypeptide comprises a second vector subunit; the first vector subunit is I53-50A1, and the second vector subunit is I53-50B.4PT1. In the self-assembled nanoparticle, the gB protein of the EB virus is displayed on the surface of the nanoparticle for the first time. The particle size of the self-assembled nanoparticle is larger than that of the antigen gB, and the chemical stability of the self-assembled nanoparticle is higher than that of the antigen gB, and the binding capacity with the neutralizing antibody of the self-assembled nanoparticle are higher than that of the antigen gB.