XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary

US12098168B2 · kind B2 · utility

Assignee

• Genomatica, Inc. · US

Inventors

• Stephen Thomas Payne · South San Francisco, US
• Scott Frykman · San Francisco, US
• Bernardo Moura Torres Da Costa · South San Francisco, US
• Isolde Callihan · South San Francisco, US
• Sankaranarayanan VENKITESWARAN · South San Francisco, US
• Leland Ken Wong · South San Francisco, US

Key dates

• Filing date: Aug 29, 2019
• Grant date: Sep 24, 2024
• Expiry date: Sep 28, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02E50/10
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids and fatty acid derivatives from cellulosic biomass, xylose, and/or a glucose/xylose mix by employing the host cells expressing the engineered XylR variants and compositions of biologically produced fatty acids and fatty acid derivatives.